In the case of native TRPM4 channels, NBA was the most potent blocker, with an IC50 of 0.13 μM in the HCT116 colorectal cancer cell line [133], while LBA was slightly less potent compared to CBA (IC50 values of 1.84 and 1.17 μM, respectively). Here, TRPM4 is linked to colorectal cancer.