An elevated higher oxygen consumption rate and extracellular acidification rate of TRPA1 deficient cells indicated that TRPA1 may play a role in the activity or development of CD8+ T cells [63] Absence of TRPA1 has been shown to profoundly influence melanoma progression, which may be related to a difference in immune surveillance of TRPA1 deficient mice [63]. Here, CD8A is linked to melanoma.