FAAH and osteoarthritis: Both irreversible (e.g., URB597) and reversible (e.g., OL-135) inhibitors of FAAH produce pharmacological effects similar to those observed in FAAH −/− mice, including antinociception in various animal models of pain using thermal or chemical nociceptive stimuli [26], and consistent anti-hyperalgesic effects in carrageenan-induced inflammation [27], complete Freund’s adjuvant-induced osteoarthritis [28], as well as in models of neuropathic pain [29].