Both germline and somatic LNK mutations have been identified in a range of haematological diseases, including myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS), MDS/MPN overlap syndromes and acute lymphoblastic leukaemia (both B and T lineage) [41,42,43,44,45,46,47]. Here, SH2B3 is linked to acute lymphoblastic leukemia.