Aberrant transcriptional rewiring towards STAT3 has emerged as the master effector/mediator of all the different (cis and trans-presentation) types of the signaling nodes in type 2 alveolar cells, macrophages, extracellular matrix, T-lymphocytes, and blood, consequently triggering the majority of symptoms observed in hospitalized patients with COVID-19, including proinflammatory conditions, profibrotic status, T-cell lymphopenia, and rapid coagulopathy/thrombosis [13] (Figure 2). Here, STAT3 is linked to COVID-19.