The presence of GQ sequences in the promoters of oncogenes, such as hTERT, MYC, KRAS, BCL2, and c-KIT as well as their potential for destabilizing telomere maintenance in cancer cells (and their involvement in replication and genomic instability [12,43,44,45]), has focused attention on GQs as promoter or telomeric therapeutic targets in viral and bacterial diseases as well as human cancers. This evidence concerns the gene MYC and cancer.