IL22 and Granuloma: For example, it has been shown, in cattle experimentally infected via aerosolized M. bovis, that late-stage granulomas in the lung showed greater expression of interferon gamma (IFN-γ), transforming growth factor beta (TGF-β), interleukin (IL)-10 and IL-22 mRNA than similar-late stage granulomas in the associated tracheobronchial lymph node.