The relevance of this mechanism prompted extensive research in HIV-1 transmission allowing for the identification of several types of synapses involving: susceptible cells to infection, such as CD4+ T cells or macrophages [4,9]; non-susceptible cells to infection, such as endothelial cells or dendritic cells (DCs) [10,11]; and different mechanisms of membrane dynamics [12]. This evidence concerns the gene CD4 and infection.