Similarly, Retinoid X receptors (RXRα/β/γ isoforms, members of the superfamily of intracellular hormone receptors) are varyingly important in the regulation of isoform switching among myosin heavy chain proteins during aging [62], and are also implicated in regulation processes involved in any transitions from cardiac hypertrophic states to actual heart failure [63]. This evidence concerns the gene RXRA and heart failure.