INS and type 1 diabetes mellitus: In Alkhateeb et al. [26], studies on minimum order mathematical models for the development of VP that consider variations of the glycemic profile in patients with T1DM under food intakes as well as physical activity are presented; a simulator for the development of VP with T1DM under conditions of physical activity, insulin administration and food intakes is shown in Kartono et al. [27], Resalat et al. [28], Garcia-Tirado et al. [18] and Moser et al. [29] research concerning the effects of physical activity on glucose homeostasis.