Examples of some of the work consulted are Ahmad et al. [40], developing virtual patient populations capable of simulating blood glucose metrics in patients with T1DM; Krishnamoorthy et al. [41] applying in-silico experimentation on 50 virtual patients with T2DM to find optimal insulin dose values; Smaoui et al. [42] developing a platform for the development and in-silico experimentation of experimental protocols in patient with T1DM. Here, INS is linked to type 1 diabetes mellitus.