ENPP1 and type 2 diabetes mellitus: While Chinese patients with AC + CC genotypes of the ENPP1 rs1044498 polymorphism suffered a 4-fold higher CHD risk (OR: 4.15, p < 0.01), those with T2D co-morbidity had a staggering 12-fold higher risk compared to the AA genotypes (OR: 12.81, p < 0.01), suggesting an ENPP1–T2D interaction [69].