On the other hand, Devalaraja-Narashimha et al., (2010) observed that Parp1-KO mice were metabolically less active and more susceptible to T2D characteristics including obesity, fatty tissue accumulation, insulin resistance, hyperleptinemia, and glucose intolerance following high-fat diet consumption compared to the WT group [207]. Here, PARP1 is linked to type 2 diabetes mellitus.