PRKAA1 and type 2 diabetes mellitus: Overexpression of AMPK-α1 in the liver ameliorated hepatic steatosis in hyperlipidemic T2D rats [134], while Prkaa1-specific deletion in the mAMPKα1-KO mice muscle resulted in T2D characteristics including hyperglycemia, hyperlipidemia, and increased muscle TG contents when they were fed a high-fat diet [135].