The genetic interaction of PARP1 with smoking and hyperlipidemia status significantly increased the odds of having CHD, although these were still within the protective range (ORsmoking+GG: 0.94, p = 0.031; ORhyperlipidemia+GG: 0.96, p = 0.025). The gene discussed is PARP1; the disease is coronary artery disorder.