PRKAA1 and coronary artery disorder: Although the “never smoked + AA” subjects did not have a strong association with increased CHD risk despite carrying the A risk allele (OR: 0.96, p = 0.895), the interaction between the PRKAA1 risk variant and smoking history in the “ever smoked + AA” group substantially enhanced the risk by 3-fold (OR: 3.02, p = 0.005) [60].