Our results showed that age, eosinophil ratio (EOSR), hematocrit (HCT), mean platelet volume (MPV), thrombocytocrit (PCT), platelet-larger cell ratio (P-LCR), uric acid (UA), glucose, antistreptococcal hemolysin “O” (ASO), anti-cyclic citrullinated peptide antibody (ACPA), rheumatoid factor (RF), Kellgren–Lawrence grade (K–L grade), history of hypertension, diabetes, and coronary artery disease (CAD) were associated with the risk of VTE in OA patients. This evidence concerns the gene PRTN3 and diabetes mellitus.