Our results showed that age, eosinophil ratio (EOSR), hematocrit (HCT), mean platelet volume (MPV), thrombocytocrit (PCT), platelet-larger cell ratio (P-LCR), uric acid (UA), glucose, antistreptococcal hemolysin “O” (ASO), anti-cyclic citrullinated peptide antibody (ACPA), rheumatoid factor (RF), Kellgren–Lawrence grade (K–L grade), history of hypertension, diabetes, and coronary artery disease (CAD) were associated with the risk of VTE in OA patients. The gene discussed is PRTN3; the disease is coronary artery disorder.