It is anticipated, in absolute terms, that subjects in standard clinical setup might experience a greater risk for bleeding and symptomatic VTE as compared with those included in RDBCTs, owing to the variations in personal features as well as by the exclusion criteria applied in RDBCTs (i.e., bleeding history, strong CYP3A4 inhibitors, adjuvant intervention using NSAIDs having long half-life, chronic intake of vitamin K antagonists, and severe hepatic or renal insufficiency) [56]. The gene discussed is CYP3A4; the disease is Renal insufficiency.