The locus 17q12-21 encodes several genes including ORMDL3, GSDMB, ZBPB2, and IKZF2, which in fact were linked to asthma in subsequent GWAS and eQTL analyses [4,5,26], and it is one of the most replicated asthma loci to date. This evidence concerns the gene ORMDL3 and asthma.