ORMDL3 and asthma: A large number of genome-wide association studies (GWAS) have been conducted in the field of asthma over the last couple of decades, which has led to the identification of numerous candidate asthma risk genes, most notably the 17q12-21 locus which has been replicated in several GWAS studies [4,5] and which harbors a number of likely biologic candidate genes, including ORM1-like 3 (ORMDL3) and gasdermin B (GSDMB).