Some of these genes have been described to be shared with other related diseases, such as AS, inflammatory bowel disease (IBD), RA or systemic lupus erythematosus (SLE) (Figure 1), being the most prominent genes: ERAP1, ERAP2, IL23A, IL23R, REL, RUNX3, STAT4, TLR4, TNIP1, TRAF3IP2, TYK2. The gene discussed is TYK2; the disease is inflammatory bowel disease.