In the large-scale study of genomic characterization of head neck squamous cell carcinoma (HNSCC) by The Cancer Genome Atlas Network, the major alterations are inactivating mutations of tumor suppressor genes, TP53 mutation (84%) and CDKN2A mutation or deletion (58%) in HPV negative HNSCC cases [7]. This evidence concerns the gene CDKN2A and head and neck squamous cell carcinoma.