Our results show that IL-2Rα−/− mice developed spontaneous chronic colitis with 100% penetrance from proximal through the distal colon, with both sexes affected equally between 6–14 weeks of age and presented sustained colitis with a human IBD-like remission-flare pattern as shown on fluctuating USMI signals between 6–30 weeks. Here, IL2RA is linked to Chronic colitis.