A study conducted by Eckl et al. [41] showed that a mutation in the human CERs3 gene, that causes autosomal recessive congenital ichthyosis (ARCI), is linked to ceramide synthase 3 inactivity, crucial for the synthesis of CERs with very long acyl chains. The gene discussed is CERS3; the disease is autosomal recessive congenital ichthyosis.