The mechanism of action exerted by curcumin in neuroblastoma cells involved the regulation of PTEN–Akt (phosphatase and tensin homolog-protein kinase B), NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells), and p53 (tumor protein P53), signaling, activation of the apoptosis cascade, and mitochondrial dysfunction [36]. The gene discussed is TP53; the disease is neuroblastoma.