Similarly, the comparison of sera from non-small cell lung cancer (NSCLC) patients and patients with a benign lung disease (pneumonia), as well as pleural effusion samples from NSCLC patients with those from individuals affected by tuberculosis, showed significant enrichment in Hx levels in the tumor-bearing patients [10], a result confirmed by Wang et al. [11] in a similar study on pleural effusion from lung adenocarcinoma patients. The gene discussed is HPX; the disease is Pleural effusion.