PAR1 and its main activator thrombin were found to play key roles in pathologies of the central and peripheral nervous systems, including in Parkinson’s disease, amyotrophic lateral sclerosis (ALS), glioblastoma (GBM), diabetic neuropathy (DN), and sciatic nerve injury [3,4,5,6,7]. Here, F2R is linked to amyotrophic lateral sclerosis.