Thus, the influence of maternal autoantibodies is probably a decisive factor for part (up to 18%) of the autism spectrum [28,29]; the cap-dependent translation initiation gene, EIF4E, is one of the most MIA-dysregulated of all ASD-associated genes, and the Tsc2/mTOR/eIF4e pathway is the most MIA-upregulated pathway [21]. The gene discussed is EIF4E; the disease is autism.