KIT and neuroblastoma: In SK-N-SH cells, however, KIT H showed a stronger inhibition of PGE2 than KIT C. Since we compared two different types of cells, namely neuroblastoma (neuronal) and microglial cells, the observed digressing effects might be explained by differences in GPR55 density on the cell surface, coupled Gα proteins, and associated downstream pathways as shown for other GPCRs.