The more common and less destructive forms can phenotypically manifest as nonsyndromic, even if they involve the same gene, such as in the Van der Woude syndrome; this is the most common syndrome that is accompanied by CL/P in 15% of patients [5] and linked to mutations in the IRF6 gene (locus 1q32-q41). This evidence concerns the gene IRF6 and van der Woude syndrome.