Despite the discussion that Breg may play a role in the CTCL progression, IL-10 produced by Bregs enriched in CD19+ CD24hiCD27+ B-cells could impair the function of immune cells, including Th1/CD8+/NK cells, or TGF-β secreted by Bregs could convert CD4+  T-cells into Tregs that would promote tumor progression [54]. The gene discussed is TGFB1; the disease is neoplasm.