In SS, fibroblasts contribute to the Th2 microenvironment by producing CCL26, which attract CCR3+ eosinophils (Figure 8); and by secreting periostin upon IL-4 and IL-13 stimulation, which will mediate TSLP production by keratinocytes and will activate immature DCs (Figure 9) [64]. This evidence concerns the gene IL4 and synovial sarcoma.