Some studies have shown that Hyp mice have abnormal renal prostaglandin production, as FGF23-mediated upregulation of prostaglandin E2 (PGE2) via inhibition of proximal tubule phosphate transport may also contribute to hypophosphatemia; this leads to defective mineralization of bones by increasing calcitriol concentration in both animals and humans [11]. This evidence concerns the gene FGF23 and hypophosphatemia.