ERBB2 and neoplasm: For instance, incorporation of p-acetylphenylalanine (pAcF) into an anti-Her2 (Herceptin) antibody Fab, and conjugation to an auristatin derivative using oxime linkage, enhanced the in vitro cytotoxic effect of anti-Her2 against Her2 (Herceptin) positive tumor cells in xenograft typical rodents [242].