As it was shown on ox-LDL induced HUVECs angiogenesis, TMP and PF treatment (separately and in combination) inhibited VEGF and VEGFR2 expression and decreased expression of angiogenesis-related factors Notch1 (NOTCH1), Jagged1 (JAG1), and Hes1 (HES1), which might contribute to the stability of plaques in atherosclerosis [83]. The gene discussed is NOTCH1; the disease is atherosclerosis.