AGTR1 and coronary artery disorder: The phosphorylation of serine/threonine residues of AT1R’s cytoplasmic tail by G protein receptor kinase activates the cascade of signal transduction, and even single-nucleotide polymorphisms of the AT1R gene are linked to an increased risk of cardiovascular risk factors, such as hypertension [17], coronary artery disease [18] and myocardial infarction [19].