Moreover, among SSc patients, the presence of AT1R-AAs and ETAR-AAs can predict the development of pulmonary arterial hypertension (PAH) and its associated mortality, suggesting the ability of these autoantibodies to increase vascular endothelial reactivity and to induce pulmonary vasculopathy [4]. The gene discussed is EDNRA; the disease is pulmonary arterial hypertension.