Additionally, KCNQ1OT1 expression is upmodulated in methotrexate-resistant colorectal cancer cells, and KCNQ1OT1 silencing re-sensitizes resistant cells to methotrexate through downregulating cAMP-response element binding protein (CREB) and CREB-binding protein (CBP) levels [146]. Here, KCNQ1OT1 is linked to colorectal cancer.