ATF2 and esophageal cancer: Exosomal AFAP1-AS1 can enter esophageal cancer cells and interact with miR-26a to promote the level of cyclic AMP-responsive element-binding protein 2 (CREB2, also known as activating transcription factor 2 (ATF2)), thereby boosting migration/invasion in vitro and lung metastasis in vivo [114] (Figure 3 and Table 2).