HNRNPA2B1 and amyotrophic lateral sclerosis: Interestingly, the NiV W protein was found to interact with hnRNPA2B1, a protein known to be involved in proteinopathy and amyotrophic lateral sclerosis (ALS), to exhibit an intrinsic tendency to assemble into self-seeding fibrils and to be incorporated in stress granules [114].