In addition, there are also asserted acupuncture abilities to augment post-ischemia CBF by promoting VEGF and angiogenin-1-mediated angiogenesis [82] and the improved release of vasoactive mediators (i.e., acetylcholine and NO); moreover, it can improve regional energy metabolism, regulate blood lipid metabolism to resist cerebral free radical damage, reduce the number of excitatory amino acids to lower neurogenic toxicity, and reduce calcium overloading [70]. Here, VEGFA is linked to ischemia.