Another study on the role of HSP90 in the development of BPH was carried out on a murine model with induced prostate hyperplasia and on human cell lines (LNCaP, BPH-1, WPMY-1), where the role of NAD(P)H-quinone oxidoreductase 1 (NQO1) was analyzed, a FAD-dependent flavoprotein, involved in the defense processes in the cell and preventing the degradation of the p53 protein, in the exacerbation of prostate tissue cell hyperplasia [114]. Here, NQO1 is linked to benign prostatic hyperplasia.