In the study on a murine model, the loss of AR from the cells of the fibromuscular stroma leads to the inhibition of the development of the intraepithelial neoplastic process PIN (prostatic intraepithelial neoplasia), the reduction of epithelial proliferation and the remodeling of the extracellular matrix (ECM). The gene discussed is AR; the disease is prostate intraepithelial neoplasia.