In contrast, Niinimaki et al. showed positive CA IX staining in the adventitia (at the vicinity of the media) of a dilated ascending aorta wall [26], and Wang et al. detected nuclear HIF-1α immunostaining in adventitia of human and mice abdominal aortic aneurysm tissues [9]. This evidence concerns the gene HIF1A and abdominal aortic aneurysm.