LMX1A and Parkinson disease: Transplantation of human astrocytes reprogrammed by NeAL218 (Neurod1, Ascl1, Lmx1a, and microRNA miR218) can generate induced DA neurons (iDANs) directly in vivo, which are capable of expressing typical DA neuron markers, adopting mature neuronal morphology and functionality, and rescuing some of the motor behavior in PD animal models.