Likewise, mature DA neurons were generated from iNPCs forced expression of Nurr1 and Foxa2, but the neuronal maturity of engrafted neurons was different between in vivo and in vitro when the iNPCs were transplanted into the striatum of PD rats [95], which may result from poor graft quality, immune response or poor host microenvironment. This evidence concerns the gene NR4A2 and Parkinson disease.