We assessed the effects of 5 weeks of dual blockade of TNF and IL-17A, TNF inhibitor monotherapy, and IL-17A inhibitor monotherapy, compared to vehicle control, on the severity and the extent of spondyloarthritis manifestations in the M. tub.-induced HLA-B27/huB2m tg rats (Figure 1a). This evidence concerns the gene TNF and spondyloarthropathy.