Moreover, in the kidneys of type 2 diabetic mice, an increase in X-box binding protein 1 (XBP1s), an endoplasmic reticulum (ER) stress-inducible transcription factor, promoted the expression of SET7/9 with augmented recruitments of SET7/9 and H3K4me1 on the promoters of monocyte chemoattractant protein-1 (MCP-1) [80]. Here, SETD7 is linked to type 2 diabetes mellitus.