Regulatory T cell (FoxP3+) infiltrates in tumor tissues increased in tumors receiving SBRT only (mean density 0.44% pre-treatment vs. 1.24% post-treatment, fold change: 2.24) whereas Treg density was reduced following treatment in animals treated with SBRT plus immunotherapy (mean density: 0.84% pre-treatment vs. 0.423% post-treatment, fold change: 0.607) (Figure 1). This evidence concerns the gene FOXP3 and neoplasm.