Furthermore, miR-223 mediates overexpression of TAL1-induced growth of T-ALL cells through the direct inhibition of the expression of the tumour suppressor F-box/WD repeat-containing protein 7 (FBXW7), which has been shown to repress MYC, MYB, NOTCH1, and CYCLIN E expression [112]. This evidence concerns the gene NOTCH1 and acute lymphoblastic leukemia.