CLCNKB and hypertensive disorder: Additionally, we predicted a common protein-coding gene network for the three biofluids, finding among the nodes with highest degree several transcripts known to be associated with albuminuria development and progression of kidney damage in hypertension, such as: SMAD3, WNT7B, BMP6 and PDGFRB (TGF-β signaling) [44]; YWHAQ, STK24, SLC12P6, CLCNKA and CLCNKB (kidney urinary concentration mechanisms) [45]; YWHAQ, PRKAG3, PRKAB2 and TRIB2 (MAPK regulation); and YWHAQ, GRIP1, RAB3IL1, HOOK1 and CYTH1 (membrane trafficking) [46,47].