CLTC and renal fibrosis: The GO and KEGG pathway analyses assessing biological functions enriched in response to albuminuria highlighted several pathways: modulators in the renal epithelial–mesenchymal transition (MAPK binding, TGF-β receptor and IL-17 signaling pathway), renal fibrosis (Wnt-protein binding, sphingolipid signaling and metabolism), endocytosis (clathrin heavy chain binding and store-operated calcium channel (SOCC) activity) and ECM constituent (SOCC activity and laminin binding).