Another promising biomarker for sepsis and septic shock is proadrenomedullin (pro-ADM), a 48-amino-acid peptide derived from adrenomedullin, which is produced by vascular endothelial cells and smooth muscle cells and exerts biological effects on vasodilatation, bronchodilatation, natriuresis, cardiac contractility, and glomerular filtrate rate. The gene discussed is ADM; the disease is Sepsis.