Interestingly, Gln is also important for maintaining cellular stemness features in BC cells (MCF-7 and MDA-MB-231 cell lines) and its deprivation pushes them towards an epithelial phenotype, as assessed by changes in the expression levels of several mesenchymal and epithelial markers (E-cadherin, N-cadherin, and claudin-1) and their intracellular distribution [167]. This evidence concerns the gene CDH1 and breast cancer.