GPX8 is overexpressed in basal B BC cell lines and its expression is strongly increased during TWIST-mediated induction of EMT in human mammary epithelial cells; interference with GPX8 expression in MDA-MB-231 cells causes MET, as evidenced by the acquisition of an epithelial morphology and by the loss of mesenchymal markers, migration capacity, and cancer stemness. Here, GPX8 is linked to cancer.