Similarly, the role of glutaminolysis on EMT is controversial: if on the one hand it induces EMT through the glutaminase GLS1 which activates the EMT-TF SNAIL1, on the other hand the expression of the mitochondrial glutaminase GLS2 has an opposite effect on the same SNAIL1 and inversely correlates with the prognosis in hepatocellular cancer [63,64]. The gene discussed is GLS; the disease is hepatocellular carcinoma.