CYP7B1 and neoplasm: LDL cholesterol promotes proliferation and migration, while CYP7B1 overexpression arrests growth and decreases migration of ATC cell lines, suggesting that cholesterol and intra-tumor accumulation of 27-HC promote progression of PTC [197].CYP7B1 ↓ ⇒ 27-HC ↑ ⇒ EMT