In light of the abovementioned data, this depicts a sort of self-sustaining loop, i.e., once the cells receive an EMT stimulus they are forced to a metabolism rewiring that sustains/contributes to the enhancement of the EMT itself (Figure 2) [153].Mesenchymal-like cancer cells ⇒ GM-CSF ↑ ⇒ TAM ⇒ CCL18 ↑ ⇒ EMT in cancer cellsMesenchymal-like cancer cells ⇒ Lactate ⇒ Proinflammatory cytokines↓. This evidence concerns the gene CSF2 and cancer.