Its disruption, by inhibiting sphingosine kinase 1 (SPHK1), which induces EMT through autophagic degradation of E-cadherin [207], or its derivate sphingosine 1-phosphate (S1P), which induces EMT through the matrix metalloproteinase-7 (MMP-7)/TGFβ autocrine loop [208], could be considered to be promising therapeutic approaches against HCC metastasis [201]. The gene discussed is SPHK1; the disease is hepatocellular carcinoma.