MTHFD2 and hereditary clear cell renal cell carcinoma: Indeed, proteins involved in metabolism often have “moonlighting” functions; in particular, MTHFD2 has been involved in RNA processing and translation by direct interaction with nuclear factors involved in RNA metabolism and translation [184], and has recently been involved (albeit in renal cell carcinoma) in the M6A methylation of HIF-2α mRNA, thus, contributing to its expression and to the promotion of aerobic glycolysis [185].MTHFD2 ↑ (moonlighting function) ⇒ AKT/GSK3β/β-catenin ↑ ⇒ EMT