In addition, these modulations are due to alterations in the FAK–PI3K–AKT axis (phosphorylation status/activation) and the functional outcome is a modulation of cell migration and invasion (cellular models, NSCLC cell lines A549 and SPCA-1) (Figure 3) [175].ENO1↑ ⇒ FAK-PI3K-AKT ↑ ⇒ SNAIL, CDH2, VIM ↑ & CDH1 ↓. The gene discussed is PTK2; the disease is non-small cell lung carcinoma.