PKM and cancer: Importantly, FBP1 suppression is also linked to the ability of cancer cells to form tumorspheres and to the acquisition of CSC markers (Figure 2) [43].SNAIL ⇒ FBP1 ↓ ⇒ F1,6BP ↑ ⇒ PKM2 ↑ (1) // FBP1 ↓ ⇒ OXPHOS ↓ (2) // (1) and (2) ⇒ lactate ↑ // (2) ⇒ ROS ↓ ⇒ β catenin activity ↑ ⇒ tumorigenicity (in vitro and in vivo) ↑