In an in vivo mouse model, the researchers have shown that after primary tumor implantation, growth, and surgical resection, the treatment of mice with fluvastatin was able to strongly reduce metastasis formation and to prolong overall survival, highlighting the role of protein N-glycosylation in cancer metastasis in the context of cells that underwent EMT [166].SNAIL ⇒ EMT ⇒ dolichol ↑ ⇒ N-glycans structures ↑Mevalonate ⇒ olichol synthesis ↓ ⇒ N-glycans structures ↓. The gene discussed is SNAI1; the disease is cancer.