Even though CSC EMT has similarities with the one described for other non-stem cells, such as acquisition of migratory properties, and is mediated by the expression of the same EMT-TFs and architectural factors, such as SNAIL1, ZEB1, TWIST, and HMGA1, in CSCs, it implies some peculiar aspects, such as loss of contacts with the niche and promotion of tumor-initiating ability [73]. Here, ZEB1 is linked to neoplasm.