GPX8 is overexpressed in basal B BC cell lines and its expression is strongly increased during TWIST-mediated induction of EMT in human mammary epithelial cells; interference with GPX8 expression in MDA-MB-231 cells causes MET, as evidenced by the acquisition of an epithelial morphology and by the loss of mesenchymal markers, migration capacity, and cancer stemness. The gene discussed is GPX8; the disease is breast cancer.