Some studies have also measured the γ-carboxylation status of MGP by immunohistochemical staining, which showed the presence of ucMGP in skin biopsies of VKCFD1 patients, who were reported with skin hyper-laxity ((GGCX:p.(V255M);p.(S300F), GGCX:p.(R83W);p.(Q374X), and GGCX:p.(S741LfsX100), GGCX:c.373+3G>T) [12,56,57]. This evidence concerns the gene MGP and vitamin K-dependent clotting factors, combined deficiency of, type 1.