On the contrary, the genes COL6A2, LAMC2, LAMB3, SDC1, ITGB4, LAMC3, COMP, and LAMA3 might play opposite effects since the regulation of actin cytoskeleton, metabolic pathways, and melanogenesis are the key pathways involved in melanoma metastasis [17,18,19]. This evidence concerns the gene COMP and melanoma.