CXCL1 expression in cancer tumors is upregulated by numerous mechanisms at almost all possible regulatory steps: gene amplification [19], the activation of transcription by high basal NF-κB activation [35], effects of pro-inflammatory cytokines on CXCL1 transcription and CXCL1 mRNA stability [46,47,48], as well as miRNAs involved in regulating CXCL1 expression in the tumor cell [112,114]. The gene discussed is CXCL1; the disease is cancer.