HMGCR and metabolic dysfunction-associated steatotic liver disease: One mechanistic explanation to NAFLD priming by De Jesus et al. suggests that downregulation of NREP increases protein expression of ATP-citrate lyase (ACLY) and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) [166], two enzymes involved in cholesterol and fatty acids biosynthesis [167].