Although Chu et al. [58] report that high chemerin with low adiponectin increase the risk of MetS with an odds ratio of 5.8, a recent report by Shafer-Eggleton et al. [59] suggests that while the chemerin/HDL-C ratio can be a superior biomarker and better predictor of nascent MetS than hsCRP, the chemerin/adiponectin ratio is not significant after adjustment for waist circumference [59]. The gene discussed is ADIPOQ; the disease is metabolic syndrome.