In the spinal cord, following the induction of various models of cancer-induced pain, imbalances on the levels of miRNAs have been found: down-regulation of miR-124, which negatively regulated synaptopodin (Synpo), a key component in synaptic transmission [65]; up-regulation of miRNA-330, which seems to modulate the expression of GABABR2 [83]; and decreases in miR-135-5p, which regulated JAKs/Stat3 signalling, in spinal astrocytes [70]. This evidence concerns the gene SYNPO and cancer.