Zhang and colleagues demonstrated that spinal piRNA-DQ541777 (piR-DQ541777) was significantly increased in mice subjected to CCI-induced neuropathic pain which indirectly, via recruiting DNMT3a, repressed the expression of CDK5 regulatory subunit-associated protein 1 (Cdk5rap1, Figure 4B) [90]. The gene discussed is CDK5RAP1; the disease is Pain.