Consistently, under the adipocyte specific-promoter of the AdipoQ gene, CRE-mediated Bscl2 deletion leads to early (6 to 12 weeks of age) and severe lipodystrophy with a massive loss of gonadal and subcutaneous WAT and a 80% decrease in circulating adiponectin [42]. This evidence concerns the gene BSCL2 and lipodystrophy.