CDK1 and colorectal carcinoma: The investigated complexes reduced the survival of human CRC HT-29 and HCT-116 cell lines, caused cell cycle arrest in the G2/M phase, and decreased expression of cyclin B1 and cyclin-dependent kinase 1 (Cdk1) was observed with an increase in regulation of the active form of p53, p21, and Bcl-2 associated with X (Bax) [87].