MAPT and Alzheimer disease: Several studies have demonstrated the capacity for seeding and spreading of tau-enriched fractions of brain homogenates from AD and other human and mouse tauopathies following intracerebral inoculation into transgenic mice bearing human tau or mutant human tau [8,9,11,12,16] and into WT and tgWT mice [9,13,14,15,16,22,23,24,25,26].