MAPT and Alzheimer disease: Thus, inoculated homogenates, regardless of their primary tau composition, be it 3Rtau plus 4Rtau (from AD and PART cases), only 4Rtau (obtained from pure ARTAG, PSP, GGT, and FTLD-P301L cases), or 3Rtau (obtained from PiD cases), produce 3Rtau and 4Rtau deposits in WT mice [22,23,24,25,26].