Similarly, brain lysates of tau P301S Tg mice with filamentous tau injected into the hippocampus and overlaying cerebral cortex of WT tau ALZ17 mice, and injection with human post-mortem brain lysates from donors with confirmed neuropathology of AD and primary tauopathy induces GVBs immunoreactive for CK1δ and pPERK [33]. Here, MAPT is linked to Alzheimer disease.