hTau mice, but not WT mice, inoculated with sarkosyl-insoluble fractions of AD homogenates show cytoplasmic granules in neurons with cytoplasmic tau deposits; these granules are immunoreactive with anti CK1-δ, CLK1, GSK-3β-PSer9, p38-PThr 180/Tyr182, PKA α/β Tyr197, and SAPK/JNK-P Thr183/Thr185 antibodies. This evidence concerns the gene MAPT and Alzheimer disease.