The present study analyzes the characteristics of tau seeding and spreading following intrahippocampal inoculation of insoluble tau (sarkosyl-insoluble fractions) from the same AD case to three murine models expressing different forms of tau: WT (murine 4Rtau), hTau (homozygous transgenic mice knock-out for murine tau protein and heterozygous expressing human forms of 3Rtau and 4Rtau proteins) [27,28], and mtWT (homozygous transgenic mice knock-out for murine tau protein). This evidence concerns the gene MAPT and Alzheimer disease.