MAPT and Alzheimer disease: WT mice unilaterally inoculated with AD sarkosyl-insoluble fractions in the hippocampus gyrus at six months and killed at nine months (three months of survival) showed abnormal tau deposition, as revealed with the antibody AT8, in neurons of the dentate gyrus, cerebral cortex near the site of inoculation, CA1 region of the hippocampus, and threads and glial cells in the fimbria and ipsilateral corpus callosum (Figure 4B–E).